FOXP2, retinoic acid, and language: a promising direction
نویسندگان
چکیده
منابع مشابه
FOXP2, retinoic acid, and language: a promising direction
Devanna et al. (2014) have demonstrated that FOXP2 mimics, and actually potentiates, retinoic acid (RA) induction of genes involved in neural differentiation. At the physiological level this effect results in an increase of neurite outgrowth and branching, and in a reduction of neuronal migration. The authors highlight the importance of RA signaling for brain growth and differentiation, and the...
متن کاملTalking Convergence: Growing Evidence Links FOXP2 and Retinoic Acid in Shaping Speech-Related Motor Circuitry
A commentary on FOXP2 drives neuronal differentiation by interacting with retinoic acid signaling pathways FOXP2 was the first identified monogenic cause of a speech disorder (for review see Graham et al., 2015). However, it remains to be answered how it affects the development of speech related neuronal circuits and what the relevant molecular pathways may be. Devanna et al. (2014) reported a ...
متن کاملRetinoic Acid Syndrome: A Case Report and Review
Background: The treatment of acute promyelocy!c leukemia with all-trans-re!noic acid (ATRA) some!mes results in a syndrome characterized by fever, respiratory distress, weight gain, pleural or pericardial effusion, and pulmonary infiltrates. We report the major clinical and radiologic features of ATRA syndrome. Materials and Methods: In the past, occasional case reports and literature pertainin...
متن کاملFOXP2 drives neuronal differentiation by interacting with retinoic acid signaling pathways
FOXP2 was the first gene shown to cause a Mendelian form of speech and language disorder. Although developmentally expressed in many organs, loss of a single copy of FOXP2 leads to a phenotype that is largely restricted to orofacial impairment during articulation and linguistic processing deficits. Why perturbed FOXP2 function affects specific aspects of the developing brain remains elusive. We...
متن کاملFOXP2 as a molecular window into speech and language.
Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome characterized by impaired speech development and linguistic deficits. Recent genomic investigations indicate that its downstream neural targets make broader impacts on common language impairments, bridging clinically distinct disorders. Moreover, the striking conservation of both FoxP2 sequence and neural expressio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2014
ISSN: 1662-5102
DOI: 10.3389/fncel.2014.00387